Decreased regional gray matter volume in S’ allele carriers of the 5-HTTLPR triallelic polymorphism

Decreased regional cortical gray matter volume in schizophrenia.

OBJECTIVE The authors hypothesized that cortical gray matter volume reduction in schizophrenia is greatest in the heteromodal association cortex. This area comprises a highly integrated, reciprocally interconnected system that coordinates higher order cortical functions. METHOD Total brain and regional gray matter volumes were calculated in 46 schizophrenic patients and 60 age and sex-matched...

COMT Val158Met × SLC6A4 5-HTTLPR interaction impacts on gray matter volume of regions supporting emotion processing.

There have been several reports on the association between the Val(158)Met genetic polymorphism of the catechol-O-methyltransferase (COMT) gene, as well as the serotonin transporter-linked polymorphic region (5-HTTLPR) of the serotonin transporter gene (SLC6A4), and frontolimbic region volumes, which have been suggested to underlie individual differences in emotion processing or susceptibility ...

Association of the long allele of the 5-HTTLPR polymorphism with compulsive craving in alcohol dependence.

AIMS Various studies have reported a role of the serotonin transporter-linked polymorphic region (5-HTTLPR) in alcoholism. METHOD The present study investigated an association of this polymorphism with obsessive-compulsive alcohol craving in 124 male patients admitted for alcohol detoxification treatment. RESULTS We found significantly higher compulsive craving in patients with the long all...

Seasonal changes in brain serotonin transporter binding in short 5- HTTLPR-allele carriers but not in long-allele homozygotes

5-HTTLPR S-allele: a genetic plasticity factor regarding the effects of life events on personality?

The S-allele of the 5-HTTLPR has been identified as a genetic vulnerability factor, being associated with an increased risk for affective disorders and/or maladaptive traits (e.g. neuroticism), especially after exposition to negative life-events (LEs). Alternatively, it has been hypothesized that this genetic risk factor might constitute a genetic plasticity factor. That is, S-allele carriers a...